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4-hydroperoxy cyclophosphamide
CAS No. 39800-16-3
4-hydroperoxy cyclophosphamide ( —— )
产品货号. M34777 CAS No. 39800-16-3
4-Hydroperoxy cyclophosphamide 是前体 Cyclophosphamide 的活性代谢产物形式。4-Hydroperoxy cyclophosphamide 交联 DNA，诱导 T 细胞不依赖于 caspase 受体激活的凋亡，可以通过产生活性氧 (ROS) 激活线粒体死亡途径。4-Hydroperoxy cyclophosphamide 可用于类风湿性关节炎和自身免疫性疾病的研究。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥2972 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称4-hydroperoxy cyclophosphamide
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述4-Hydroperoxy cyclophosphamide 是前体 Cyclophosphamide 的活性代谢产物形式。4-Hydroperoxy cyclophosphamide 交联 DNA，诱导 T 细胞不依赖于 caspase 受体激活的凋亡，可以通过产生活性氧 (ROS) 激活线粒体死亡途径。4-Hydroperoxy cyclophosphamide 可用于类风湿性关节炎和自身免疫性疾病的研究。
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产品描述4-Hydroperoxy cyclophosphamide is the active metabolite form of the precursor Cyclophosphamide. 4-Hydroperoxy cyclophosphamide cross-links DNA to induce T cell apoptosis independent of caspase receptor activation, and can activate the mitochondrial death pathway by producing reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide can be used in the study of rheumatoid arthritis and autoimmune diseases.
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体外实验Western Blot Analysis Cell Line:CTL Concentration:3 μg/mL Incubation Time:24, 48, 72 hResult:Increased the expression of p53 and Bax after 24 h.Apoptosis Analysis Cell Line:Jurkat, CTL Concentration:1 or 3 μg/mL Incubation Time:24 , 48 , 72h Result: Caspase-8 deficiency prevented CD95-mediated death induced by anti-CD95 monoclonal antibody (mAb) APO-1.Overexpression of Bcl-2 inhibited apoptosis. Induced cell death proceeded independently of caspase inhibition.
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体内实验Animal Model:BALB/c mice Dosage:200 mg/kg Administration:i.p.Result:Exhibited a marked depletion of immature double-positive CD4 t CD8 t thymocytes and mature single-positive CD4+ and CD8+ T cells.
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同义词——
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通路Others
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靶点Other Targets
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受体Reactive Oxygen Species | DNA Alkylator/Crosslinker | Apoptosis | Drug Metabolite
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研究领域——
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适应症——
化学信息
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CAS Number39800-16-3
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分子量293.09
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分子式C7H15Cl2N2O4P
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 50 mg/mL (170.60 mM; 超声助溶 )
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SMILESO=P1(OCCC(OO)N1)N(CCCl)CCCl
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Strauss G, et al. 4-hydroperoxy-cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG. Cell Death Differ. 2008 Feb;15(2):332-43.?
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